Philpot lab


Click here to see all Philpot lab publications.

Representative publications:

Sidorov, M.S., Kim, H., Rougie, M., Williams, B., Siegel,J. , Gavornik, J., Philpot, B. D. (2020). Visual Sequences Drive Experience-Dependent Plasticity in Mouse Anterior Cingulate Cortex. Cell Reports, 32, 11, 9.

Gu, B., Shorter, J.R., Williams L.H., Bell, T.A., Hock, P., Dalton, K.A., Pan, Y., Miller, D.R., Shaw, G.D., Philpot, B.D., Pardo-Manuel de Villena F (2020). Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility. Epilepsia. Sep;61(9):2010-2021. doi: 10.1111/epi.16617.

Lee, H. M., Clark, E. P., Kuijer, M. B., Cushman, M., Pommier, Y., & Philpot, B. D. (2018). Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome. Mol Autism, 9, 45. doi:10.1186/s13229-018-0228-2

den Bakker, H., Sidorov, M. S., Fan, Z., Lee, D. J., Bird, L. M., Chu, C. J., & Philpot, B. D. (2018). Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study. Mol Autism, 9, 32. doi:10.1186/s13229-018-0214-8

Sidorov, M. S., Judson, M. C., Kim, H., Rougie, M., Ferrer, A. I., Nikolova, V. D., . . . Philpot, B. D. (2018). Enhanced operant extinction and prefrontal excitability in a mouse model of Angelman syndrome. J Neurosci. doi:10.1523/JNEUROSCI.2828-17.2018

Judson, M. C., Burette, A. C., Thaxton, C. L., Pribisko, A. L., Shen, M. D., Rumple, A. M., . . . Philpot, B. D. (2017). Decreased Axon Caliber Underlies Loss of Fiber Tract Integrity, Disproportional Reductions in White Matter Volume, and Microcephaly in Angelman Syndrome Model Mice. J Neurosci, 37(31), 7347-7361. doi:10.1523/JNEUROSCI.0037-17.2017

Sidorov MS, Deck GM, Dolatshahi M, Bird LM, Thibert RL, Chu CJ, and Philpot BD (2017).  Delta rhythmicity is a reliable biomarker in Angelman syndrome: a parallel mouse and human analysisJ Neurodev Dis 9:17.

Jones KA, Han JE, DeBruyne JP, Philpot BD (2016) Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice. Scientific Reports 6:28238.

Mabb AM, Simon JM, King IF, Lee H-M, An L-K, Philpot BD, and Zylka MJ. (2016) Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. PLoS ONE 11(5): e0156439. doi:10.1371/journal.pone.0156439

Kim H, Kunz PA, Mooney R, Philpot BD,  Smith SL. Maternal Loss of Ube3a Impairs Experience-Driven Dendritic Spine Maintenance in the Developing Visual Cortex. J Neurosci, 2016 Apr 27;36(17), 4888-4894. doi: 10.1523/JNEUROSCI.4204-15.2016

Judson MC, Wallace ML, Sidorov MS, Burette AC, Gu B, van Woerden GM, King IF, Han JE, Zylka MJ, Elgersma Y, Weinberg RJ, Philpot BD GABAergic neuron-specific loss of Ube3a causes Angelman syndrome-like EEG abnormalities and enchances seizure susceptibility.  Neuron. 2016 Apr 6; doi:10.1016/j.neuron.2016.02.040

Berrios J, Stamatakis AM, Kantak PA, McElligott ZA, Judson MC, Aita M, Rougie M, Stuber GD, Philpot BDLoss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation. Nat Commun. 2016 Feb 12;7:10702. doi: 10.1038/ncomms10702.

Katz DM, Bird A, Coenraads M, Gray SJ, Menon DU, Philpot BD, Tarquinio DC. Rett Syndrome: Crossing the Threshold to Clinical Translation. Trends Neurosci. 2016 Feb;39(2):100-13. doi: 10.1016/j.tins.2015.12.008. Review.

Ehlen JC, Jones KA, Pinckney L, Gray CL, Burette S, Weinberg RJ, Evans JA, Brager AJ, Zylka MJ, Paul KN, Philpot BD, DeBruyne JP. Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact. J Neurosci. 2015 Oct 7;35(40):13587-98. doi: 10.1523/JNEUROSCI.2194-15.2015.

Yi JJ, Berrios J, Newbern JM, Snider WD, Philpot BD, Hahn KM, Zylka MJ. An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A. Cell. 2015 Aug 13;162(4):795-807. doi: 10.1016/j.cell.2015.06.045. Epub 2015 Aug 6.

Zylka MJ, Simon JM, Philpot BDGene length matters in neurons. Neuron. 2015 Apr 22;86(2):353-5. doi: 10.1016/j.neuron.2015.03.059.

Mabb AM, Kullmann PH, Twomey MA, Miriyala J, Philpot BD, Zylka MJ. Topoisomerase 1 inhibition reversibly impairs synaptic function. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17290-5. doi: 10.1073/pnas.1413204111.

Larsen RS, Smith IT, Miriyala J, Han JE, Corlew RJ, Smith SL, Philpot BDSynapse-Specific Control of Experience-Dependent Plasticity by Presynaptic NMDA Receptors. Neuron. 2014 Aug 20;83(4):879-93. doi: 10.1016/j.neuron.2014.07.039.

Judson MC, Sosa-Pagan JO, Delcid WA, Han JE, Philpot BDAllelic specificity of Ube3a expression in the mouse brain during postnatal development.   J Comp Neurol. 2013 Nov 20.

King IF, Yandava CN, Mabb AM, Hsiao JS, Huang HS, Pearson BL, Calabrese JM, Starmer J, Parker JS, Magnuson T, Chamberlain SJ, Philpot BD, Zylka MJ.Topoisomerases facilitate transcription of long genes linked to autism. Nature. 2013 Sep 5;501(7465):58-62.

Kunz PA, Roberts AC, Philpot BDPresynaptic NMDA receptor mechanisms for enhancing spontaneous neurotransmitter release. J Neurosci. 2013 May 1;33(18):7762-9.

Huang HS, Burns AJ, Nonneman RJ, Baker LK, Riddick NV, Nikolova VD, Riday TT, Yashiro K,Philpot BD, Moy SS. Behavioral deficits in an Angelman syndrome model: effects of genetic background and age. Behav Brain Res. 2013 Apr 15;243:79-90. doi: 10.1016/j.bbr.2012.12.052. Epub 2013 Jan 4.

Riday TT, Dankoski EC, Krouse MC, Fish EW, Walsh PL, Han JE, Hodge CW, Wightman RM, Philpot BD, Malanga CJ. Pathway-specific dopaminergic deficits in a mouse model of Angelman syndrome. J Clin Invest. 2012 Dec 3;122(12):4544-54

Wallace ML, Burette AC, Weinberg RJ, Philpot BDMaternal loss of Ube3a produces an excitatory/inhibitory imbalance through neuron type-specific synaptic defects. Neuron. 2012 Jun 7;74(5):793-800.

Huang HS, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW Jr, Lee HM, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD.Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature. 2011 Dec 21;481(7380):185-9. doi: 10.1038/nature10726.

Larsen RS, Corlew RJ, Henson MA, Roberts AC, Mishina M, Watanabe M, Lipton SA, Nakanishi N, Pérez-Otaño I, Weinberg RJ, Philpot BDNR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity. Nat Neurosci. 2011 Mar;14(3):338-44. doi: 10.1038/nn.2750. Epub 2011 Feb 6.

Yashiro K, Riday TT, Condon KH, Roberts AC, Bernardo DR, Prakash R, Weinberg RJ, Ehlers MD, Philpot BD. Ube3a is required for experience-dependent maturation of the neocortex. Nat Neurosci. 2009 May 10. [Epub ahead of print]

Corlew R, Wang Y, Ghermazien H, Erisir A, Philpot BD. (2007) Developmental switch in the contribution of presynaptic and postsynaptic NMDA receptors to long-term depression. J Neurosci. 2007 Sep 12;27(37):9835-45.

Yashiro K, Corlew R, Philpot BD. (2005) Visual deprivation modifies both presynaptic glutamate release and the composition of peri-/extrasynaptic NMDA receptors in adult visual cortex. Journal of Neuroscience 25:11684-11692.